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CMap Candidate Details

Structure:
CMap ID: C03536
Pert ID: BRD-K66615216
Compound Name: moxifloxacin
Targets: TOP2A
MoA: bacterial DNA gyrase inhibitor
SMILES: COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1223 BRD-K66615216 A549 10 uM 24 h -0.26 -1.1 0.34 -0.26 -0.87 0.24
1284 BRD-K66615216 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1348 BRD-K66615216 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.26 -0.86 0.22
34151 BRD-K66615216 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34661 BRD-K66615216 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34930 BRD-K66615216 HEPG2 10 uM 6 h -0.28 -1.16 0.46 0.0 0.0 0.0
35600 BRD-K66615216 NEU 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.29
35821 BRD-K66615216 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36314 BRD-K66615216 PHH 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
36612 BRD-K66615216 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36988 BRD-K66615216 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96332 BRD-K66615216 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96403 BRD-K66615216 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125009 BRD-K66615216 HA1E 10 uM 24 h 0.25 1.05 0.17 -0.24 -0.82 0.15
125062 BRD-K66615216 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
125184 BRD-K66615216 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
125223 BRD-K66615216 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133074 BRD-K66615216 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.55
133101 BRD-K66615216 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
133180 BRD-K66615216 JURKAT 0.01 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
133209 BRD-K66615216 MCF10A 2.22 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
133272 BRD-K66615216 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).