Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C03600
Pert ID: BRD-K74141488
Compound Name: naftifine
Targets: SQLE
MoA: fungal squalene epoxidase inhibitor
SMILES: CN(C\C=C\c1ccccc1)Cc1cccc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1620 BRD-K74141488 HA1E 10 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
2118 BRD-K74141488 HCC515 10 uM 6 h -0.28 -1.16 0.47 -0.35 -1.17 1.11
2515 BRD-K74141488 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42464 BRD-K74141488 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42775 BRD-K74141488 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43642 BRD-K74141488 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43941 BRD-K74141488 PHH 10 uM 24 h -0.2 -0.84 0.01 0.22 0.8 0.08
44196 BRD-K74141488 SKB 10 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
127091 BRD-K74141488 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127130 BRD-K74141488 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
127159 BRD-K74141488 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127179 BRD-K74141488 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
127202 BRD-K74141488 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127229 BRD-K74141488 PC3 0.37 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
127271 BRD-K74141488 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135012 BRD-K74141488 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135031 BRD-K74141488 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135097 BRD-K74141488 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135250 BRD-K74141488 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135321 BRD-K74141488 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).