CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03602
Pert ID:	BRD-K66404838
Compound Name:	nalbuphine
Targets:	OPRD1\|OPRK1\|OPRM1
MoA:	opioid receptor agonist; opioid receptor antagonist
SMILES:	O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CCC1)c45
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
8721	BRD-K66404838	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91046	BRD-K66404838	HUH7	10 uM	72 h	-0.18	-0.74	0.0	0.0	0.0	0.0
95350	BRD-K66404838	MCF??7.00	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95459	BRD-K66404838	U2OS	10 uM	6 h	0.0	0.0	0.0	-0.39	-1.31	1.71
124947	BRD-K66404838	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124982	BRD-K66404838	A549	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125061	BRD-K66404838	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125084	BRD-K66404838	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125123	BRD-K66404838	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.42
125182	BRD-K66404838	THP1	10 uM	24 h	-0.23	-0.95	0.09	0.29	1.01	0.45
133022	BRD-K66404838	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133072	BRD-K66404838	HEK293	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133099	BRD-K66404838	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133301	BRD-K66404838	PC3	2.22 uM	24 h	0.26	1.08	0.21	0.0	0.0	0.0
133325	BRD-K66404838	YAPC	2.22 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0

Summary