CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03634
Pert ID:	BRD-K82746043
Compound Name:	navitoclax
Targets:	BCL2\|BCL2L1\|BCL2L2
MoA:	BCL inhibitor
SMILES:	CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9522	BRD-K82746043	AGS	10 uM	6 h	0.25	1.04	0.14	0.0	0.0	0.0
9827	BRD-K82746043	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11589	BRD-K82746043	NCIH2073	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11851	BRD-K82746043	NCIH508	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12147	BRD-K82746043	NCIH596	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13371	BRD-K82746043	U937	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13689	BRD-K82746043	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.22	-0.75	0.06
95497	BRD-K82746043	A549	10 uM	48 h	0.0	0.0	0.0	-0.34	-1.14	1.01
95653	BRD-K82746043	U2OS	10 uM	48 h	0.0	0.0	0.0	-0.34	-1.15	1.07
117463	BRD-K82746043	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117510	BRD-K82746043	HEPG2	10 uM	24 h	-0.28	-1.15	0.44	-0.31	-1.04	0.67
117554	BRD-K82746043	HT29	3.33 uM	24 h	-0.36	-1.49	1.43	0.0	0.0	0.0
126411	BRD-K82746043	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126462	BRD-K82746043	HEK293	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.35
126485	BRD-K82746043	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126566	BRD-K82746043	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126587	BRD-K82746043	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126617	BRD-K82746043	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134364	BRD-K82746043	A375	2.22 uM	24 h	0.0	0.0	0.0	0.2	0.7	0.02
134529	BRD-K82746043	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134554	BRD-K82746043	MCF10A	0.01 uM	24 h	-0.22	-0.9	0.04	-0.28	-0.94	0.37
134581	BRD-K82746043	MCF??7.00	0.01 uM	24 h	0.23	0.96	0.08	0.0	0.0	0.0

Summary