CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03651
Pert ID:	BRD-K84466663
Compound Name:	nelarabine
Targets:	POLA1
MoA:	DNA synthesis inhibitor; T cell inhibitor
SMILES:	COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
118419	BRD-K84466663	A549	10 uM	24 h	-0.24	-0.99	0.14	0.0	0.0	0.0
118489	BRD-K84466663	HCC515	1.11 uM	24 h	0.0	0.0	0.0	0.25	0.89	0.2
118535	BRD-K84466663	HEPG2	0.04 uM	24 h	0.29	1.23	0.49	-0.26	-0.87	0.23
118646	BRD-K84466663	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125564	BRD-K84466663	A375	0.04 uM	24 h	-0.26	-1.08	0.3	0.32	1.15	0.88
125626	BRD-K84466663	HA1E	3.33 uM	24 h	0.0	0.0	0.0	-0.27	-0.89	0.27
125667	BRD-K84466663	HELA	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125713	BRD-K84466663	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125763	BRD-K84466663	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125889	BRD-K84466663	THP1	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125912	BRD-K84466663	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.37	1.32	1.71
133725	BRD-K84466663	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133786	BRD-K84466663	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133843	BRD-K84466663	MCF10A	0.25 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	0.99
133874	BRD-K84466663	MCF??7.00	0.03 uM	24 h	-0.25	-1.04	0.22	0.0	0.0	0.0
133901	BRD-K84466663	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary