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CMap Candidate Details

Structure:
CMap ID: C03704
Pert ID: BRD-K81528515
Compound Name: nilotinib
Targets: ABL1|KIT
MoA: Abl kinase inhibitor; Bcr-Abl kinase inhibitor
SMILES: Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33935 BRD-K81528515 A549 10 uM 6 h 0.0 0.0 0.0 -0.48 -1.63 15.65
34186 BRD-K81528515 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35625 BRD-K81528515 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36358 BRD-K81528515 PHH 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
36656 BRD-K81528515 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36877 BRD-K81528515 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87314 BRD-K81528515 BJAB 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.93 0.35
87339 BRD-K81528515 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87389 BRD-K81528515 K562 2.5 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
87437 BRD-K81528515 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87498 BRD-K81528515 MINO 10 uM 3 h -0.32 -1.34 0.98 0.0 0.0 0.0
87540 BRD-K81528515 NALM6 10 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
87592 BRD-K81528515 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87641 BRD-K81528515 OCILY19 10 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
87692 BRD-K81528515 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87741 BRD-K81528515 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
87784 BRD-K81528515 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87842 BRD-K81528515 TMD8 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92049 BRD-K81528515 BT20 10 uM 3 h 0.0 0.0 0.0 -0.59 -2.0 15.65
92169 BRD-K81528515 HS578T 10 uM 3 h 0.0 0.0 0.0 -0.35 -1.16 1.11
92242 BRD-K81528515 MCF10A 10 uM 3 h 0.0 0.0 0.0 -0.37 -1.24 1.29
92321 BRD-K81528515 MDAMB231 0.04 uM 3 h 0.0 0.0 0.0 -0.33 -1.11 0.92
92397 BRD-K81528515 SKBR3 10 uM 3 h -0.24 -1.0 0.15 0.0 0.0 0.0
95394 BRD-K81528515 U2OS 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
95861 BRD-K81528515 NPC 3.33 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
118530 BRD-K81528515 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118574 BRD-K81528515 HT29 1.11 uM 24 h -0.18 -0.73 0.0 0.0 0.0 0.0
119414 BRD-K81528515 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119475 BRD-K81528515 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119513 BRD-K81528515 HCC515 1.11 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
126072 BRD-K81528515 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126114 BRD-K81528515 JURKAT 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
134088 BRD-K81528515 HEK293 0.25 uM 24 h 0.25 1.03 0.13 0.28 0.97 0.36
134139 BRD-K81528515 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.31
134220 BRD-K81528515 MCF??7.00 2.22 uM 24 h 0.31 1.3 0.69 0.0 0.0 0.0
134283 BRD-K81528515 PC3 0.25 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
134307 BRD-K81528515 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).