CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03711
Pert ID:	BRD-K49075727
Compound Name:	nintedanib
Targets:	FGFR1\|FGFR2\|FGFR3\|FGFR4\|FLT1\|FLT4\|KDR\|PDGFRA\|PDGFRB
MoA:	FGFR inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES:	COC(=O)c1ccc2c(NC(=O)\C2=C(/Nc2ccc(cc2)N(C)C(=O)CN2CCN(C)CC2)c2ccccc2)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91878	BRD-K49075727	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.49	1.73	2.59
92409	BRD-K49075727	A375	0.12 uM	24 h	0.0	0.0	0.0	0.22	0.77	0.06
92434	BRD-K49075727	A549	10 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.2
92464	BRD-K49075727	BT20	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92534	BRD-K49075727	HME1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92579	BRD-K49075727	HS578T	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92668	BRD-K49075727	LNCAP	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92734	BRD-K49075727	MCF10A	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
92772	BRD-K49075727	MDAMB231	10 uM	24 h	-0.2	-0.81	0.0	0.26	0.9	0.23
92852	BRD-K49075727	SKBR3	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
125325	BRD-K49075727	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125357	BRD-K49075727	HELA	10 uM	24 h	-0.25	-1.06	0.24	0.32	1.15	0.87
125380	BRD-K49075727	HT29	10 uM	24 h	0.0	0.0	0.0	-0.18	-0.59	0.0
125406	BRD-K49075727	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125527	BRD-K49075727	THP1	10 uM	24 h	0.0	0.0	0.0	-0.21	-0.69	0.02
125551	BRD-K49075727	YAPC	10 uM	24 h	0.0	0.0	0.0	0.42	1.49	2.26
133395	BRD-K49075727	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.36	1.28	1.42
133588	BRD-K49075727	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary