CMap Candidate Details
Structure:
| CMap ID: | C03739 |
| Pert ID: | BRD-K83699324 |
| Compound Name: | NMS-1286937 |
| Targets: | FLT3|PLK1|PLK2|PLK3 |
| MoA: | PLK inhibitor |
| SMILES: | CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 90855 | BRD-K83699324 | MCF10A | 10 uM | 12 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126007 | BRD-K83699324 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126133 | BRD-K83699324 | JURKAT | 1.11 uM | 24 h | -0.2 | -0.84 | 0.0 | -0.26 | -0.87 | 0.23 |
| 126304 | BRD-K83699324 | THP1 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.17 | 1.14 |
| 134010 | BRD-K83699324 | A375 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134040 | BRD-K83699324 | A549 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.86 | 0.16 |
| 134107 | BRD-K83699324 | HEK293 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.33 | 1.71 |
| 134152 | BRD-K83699324 | HELA | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.93 | 0.35 |
| 134184 | BRD-K83699324 | HT29 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134208 | BRD-K83699324 | HUVEC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134230 | BRD-K83699324 | MCF??7.00 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.33 | 1.17 | 0.94 |
| 134261 | BRD-K83699324 | MDAMB231 | 2.22 uM | 24 h | -0.27 | -1.13 | 0.41 | 0.0 | 0.0 | 0.0 |
| 134288 | BRD-K83699324 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.37 | -1.24 | 1.31 |
| 134316 | BRD-K83699324 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.95 | 0.41 |