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CMap Candidate Details

Structure:
CMap ID: C03747
Pert ID: BRD-K06753942
Compound Name: nobiletin
Targets: MAP2K1
MoA: MEK inhibitor
SMILES: COc1ccc(cc1OC)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2982 BRD-K06753942 HA1E 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.51
3136 BRD-K06753942 HCC515 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
3465 BRD-K06753942 PC3 10 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
3719 BRD-K06753942 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44289 BRD-K06753942 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44834 BRD-K06753942 ASC 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
45144 BRD-K06753942 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45412 BRD-K06753942 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45767 BRD-K06753942 MCF??7.00 10 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
45949 BRD-K06753942 NPC 10 uM 24 h -0.26 -1.09 0.33 -0.35 -1.19 1.15
46268 BRD-K06753942 PHH 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
46583 BRD-K06753942 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96108 BRD-K06753942 A549 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
100015 BRD-K06753942 U2OS 10 uM 6 h 0.28 1.19 0.41 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).