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CMap Candidate Details

Structure:
CMap ID: C03767
Pert ID: BRD-K91263825
Compound Name: nortriptyline
Targets: ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD2|HRH1|HTR1A|HTR2A|HTR2C|HTR6|KCNJ10|PGRMC1|SIGMAR1|SLC6A2|SLC6A4
MoA: tricyclic antidepressant
SMILES: CNCCC=C1c2ccccc2CCc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2941 BRD-K91263825 HA1E 10 uM 24 h 0.0 0.0 0.0 0.37 1.31 1.59
3405 BRD-K91263825 HCC515 10 uM 6 h 0.0 0.0 0.0 0.34 1.22 1.15
3889 BRD-K91263825 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45049 BRD-K91263825 ASC 10 uM 24 h -0.24 -0.99 0.13 0.26 0.93 0.26
45335 BRD-K91263825 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46159 BRD-K91263825 NPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.96
46474 BRD-K91263825 PHH 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
46802 BRD-K91263825 SKB 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.99
127744 BRD-K91263825 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127788 BRD-K91263825 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127868 BRD-K91263825 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
127942 BRD-K91263825 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
127995 BRD-K91263825 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128029 BRD-K91263825 MCF??7.00 10 uM 24 h 0.25 1.03 0.14 0.26 0.94 0.28
128052 BRD-K91263825 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135569 BRD-K91263825 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.9 0.22
135614 BRD-K91263825 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135660 BRD-K91263825 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
135745 BRD-K91263825 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).