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CMap Candidate Details

Structure:
CMap ID: C00379
Pert ID: BRD-K26325692
Compound Name: API-001
Targets: SIGMAR1
MoA: sigma receptor antagonist
SMILES: Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121898 BRD-K26325692 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121918 BRD-K26325692 A549 0.125 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
121936 BRD-K26325692 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.35
122054 BRD-K26325692 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
122109 BRD-K26325692 MCF??7.00 3.33 uM 24 h -0.32 -1.34 0.98 0.0 0.0 0.0
130259 BRD-K26325692 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.94
130293 BRD-K26325692 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
130321 BRD-K26325692 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130355 BRD-K26325692 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
130404 BRD-K26325692 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130453 BRD-K26325692 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130479 BRD-K26325692 PC3 0.03 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
130496 BRD-K26325692 THP1 2.22 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
130526 BRD-K26325692 YAPC 0.01 uM 24 h 0.26 1.08 0.22 -0.27 -0.92 0.32
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).