CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03793
Pert ID:	BRD-K64874225
Compound Name:	NSC-4644
Targets:	PYGM
MoA:	ACAT inhibitor; sterol regulatory element binding protein (SREBP) inhibitor
SMILES:	CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
99338	BRD-K64874225	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
124673	BRD-K64874225	HELA	0.06 uM	24 h	0.26	1.07	0.2	-0.29	-0.98	0.47
124707	BRD-K64874225	HT29	0.02 uM	24 h	0.3	1.25	0.54	0.0	0.0	0.0
124814	BRD-K64874225	MDAMB231	4 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124857	BRD-K64874225	PC3	4 uM	24 h	-0.25	-1.05	0.23	-0.3	-1.01	0.58
124898	BRD-K64874225	THP1	0.5 uM	24 h	-0.27	-1.14	0.43	-0.36	-1.2	1.21
124922	BRD-K64874225	YAPC	1.67 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.15
132673	BRD-K64874225	A375	0.12 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33
132704	BRD-K64874225	A549	0.37 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.05
132730	BRD-K64874225	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132770	BRD-K64874225	HEK293	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132846	BRD-K64874225	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132885	BRD-K64874225	MCF10A	0.01 uM	24 h	0.26	1.07	0.2	0.0	0.0	0.0
132911	BRD-K64874225	MCF??7.00	0.004 uM	24 h	-0.21	-0.86	0.02	0.0	0.0	0.0

Summary