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CMap Candidate Details

Structure:
CMap ID: C03809
Pert ID: BRD-K09537769
Compound Name: NU-7026
Targets: PRKDC
MoA: DNA dependent protein kinase inhibitor; mTOR inhibitor; PI3K inhibitor
SMILES: O=c1cc(oc2c3ccccc3ccc12)N1CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5182 BRD-K09537769 A375 10 uM 6 h -0.24 -1.01 0.17 -0.24 -0.82 0.15
6425 BRD-K09537769 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
38050 BRD-K09537769 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38910 BRD-K09537769 SKB 10 uM 24 h -0.26 -1.1 0.35 0.0 0.0 0.0
90847 BRD-K09537769 MCF10A 10 uM 24 h 0.26 1.08 0.22 0.0 0.0 0.0
93631 BRD-K09537769 A549 0.04 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
93674 BRD-K09537769 ASC 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.85
93739 BRD-K09537769 CD34 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93773 BRD-K09537769 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93813 BRD-K09537769 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
93864 BRD-K09537769 HEK293 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93904 BRD-K09537769 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93946 BRD-K09537769 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
93973 BRD-K09537769 HUVEC 3.33 uM 24 h -0.19 -0.79 0.0 -0.31 -1.05 0.72
94047 BRD-K09537769 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94076 BRD-K09537769 MCF??7.00 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94127 BRD-K09537769 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94146 BRD-K09537769 NPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94207 BRD-K09537769 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94262 BRD-K09537769 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
94313 BRD-K09537769 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94357 BRD-K09537769 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94395 BRD-K09537769 YAPC 3.33 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
100050 BRD-K09537769 U2OS 10 uM 6 h 0.0 0.0 0.0 0.21 0.76 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).