CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03816
Pert ID:	BRD-K41859756
Compound Name:	NVP-AUY922
Targets:	HSP90AA1\|HSP90AB1
MoA:	HSP inhibitor
SMILES:	CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1178	BRD-K41859756	PC3	0.08 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.63
1404	BRD-K41859756	U2OS	10 uM	6 h	0.0	0.0	0.0	0.32	1.14	0.87
9037	BRD-K41859756	A375	10 uM	6 h	-0.27	-1.13	0.41	0.0	0.0	0.0
9423	BRD-K41859756	AGS	10 uM	6 h	0.0	0.0	0.0	0.39	1.39	2.17
9728	BRD-K41859756	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10057	BRD-K41859756	HA1E	10 uM	6 h	0.0	0.0	0.0	0.27	0.96	0.33
10303	BRD-K41859756	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10515	BRD-K41859756	HCT116	10 uM	6 h	0.0	0.0	0.0	-0.34	-1.14	1.03
10786	BRD-K41859756	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11083	BRD-K41859756	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11279	BRD-K41859756	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11487	BRD-K41859756	NCIH2073	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.77	0.08
11766	BRD-K41859756	NCIH508	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.99	0.51
12051	BRD-K41859756	NCIH596	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12317	BRD-K41859756	NOMO1	10 uM	6 h	-0.32	-1.32	0.83	0.21	0.76	0.05
12791	BRD-K41859756	SW480	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13014	BRD-K41859756	THP1	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13272	BRD-K41859756	U937	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13474	BRD-K41859756	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91804	BRD-K41859756	HS578T	10 uM	6 h	-0.2	-0.84	0.01	0.0	0.0	0.0
91841	BRD-K41859756	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91913	BRD-K41859756	MDAMB231	2.22 uM	6 h	0.0	0.0	0.0	0.3	1.07	0.63
91960	BRD-K41859756	SKBR3	0.08 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
96141	BRD-K41859756	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary