CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03822
Pert ID:	BRD-K77396579
Compound Name:	NVP-DPP728
Targets:	DPP4
MoA:	dipeptidyl peptidase inhibitor
SMILES:	O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96388	BRD-K77396579	PC3	10 uM	24 h	0.24	1.02	0.13	0.3	1.07	0.63
127074	BRD-K77396579	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127107	BRD-K77396579	HELA	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127143	BRD-K77396579	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127214	BRD-K77396579	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	-0.23	-0.77	0.08
127286	BRD-K77396579	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135019	BRD-K77396579	A375	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135051	BRD-K77396579	A549	0.08 uM	24 h	0.0	0.0	0.0	0.29	1.02	0.48
135089	BRD-K77396579	HA1E	2.22 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0
135179	BRD-K77396579	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135212	BRD-K77396579	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135275	BRD-K77396579	MDAMB231	0.25 uM	24 h	0.21	0.89	0.02	-0.31	-1.04	0.65
135330	BRD-K77396579	YAPC	0.01 uM	24 h	0.0	0.0	0.0	-0.42	-1.43	15.35

Summary