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CMap Candidate Details

Structure:
CMap ID: C00384
Pert ID: BRD-K15164005
Compound Name: apoptosis-activator-II
Targets: BCHE|CES1
MoA: carboxylesterase inhibitor
SMILES: Clc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2840 BRD-K15164005 HA1E 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
3145 BRD-K15164005 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3596 BRD-K15164005 PC3 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
3728 BRD-K15164005 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.07
39093 BRD-K15164005 A375 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.26 1.35
39300 BRD-K15164005 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39632 BRD-K15164005 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39948 BRD-K15164005 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.49
40230 BRD-K15164005 HT29 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.31
40592 BRD-K15164005 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40756 BRD-K15164005 NEU 10 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
41056 BRD-K15164005 NPC 10 uM 24 h -0.15 -0.64 0.0 -0.29 -0.97 0.46
41385 BRD-K15164005 SKB 10 uM 24 h -0.26 -1.09 0.32 0.0 0.0 0.0
100129 BRD-K15164005 U2OS 10 uM 6 h -0.24 -0.99 0.14 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).