CMap Candidate Details
Structure:
| CMap ID: | C03857 |
| Pert ID: | BRD-K22822991 |
| Compound Name: | odanacatib |
| Targets: | CTSK |
| MoA: | cathepsin inhibitor |
| SMILES: | CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 120953 | BRD-K22822991 | HEK293 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121041 | BRD-K22822991 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121075 | BRD-K22822991 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121109 | BRD-K22822991 | YAPC | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129097 | BRD-K22822991 | A375 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.89 | 0.26 |
| 129115 | BRD-K22822991 | A549 | 2.22 uM | 24 h | 0.26 | 1.08 | 0.21 | 0.0 | 0.0 | 0.0 |
| 129135 | BRD-K22822991 | HA1E | 0.74 uM | 24 h | -0.26 | -1.08 | 0.29 | -0.29 | -0.97 | 0.45 |
| 129152 | BRD-K22822991 | HELA | 0.25 uM | 24 h | -0.24 | -0.98 | 0.12 | 0.0 | 0.0 | 0.0 |
| 129189 | BRD-K22822991 | HT29 | 0.74 uM | 24 h | 0.22 | 0.93 | 0.05 | -0.21 | -0.71 | 0.03 |