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CMap Candidate Details

Structure:
CMap ID: C03861
Pert ID: BRD-A24228527
Compound Name: ofloxacin
Targets: TOP2A
MoA: bacterial DNA gyrase inhibitor
SMILES: CC1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49937 BRD-A24228527 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50977 BRD-A24228527 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91290 BRD-A24228527 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
120873 BRD-A24228527 A375 10 uM 24 h 0.0 0.0 0.0 0.2 0.69 0.01
120921 BRD-A24228527 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120971 BRD-A24228527 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121021 BRD-A24228527 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121058 BRD-A24228527 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
121128 BRD-A24228527 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
129155 BRD-A24228527 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129230 BRD-A24228527 PC3 0.08 uM 24 h -0.25 -1.02 0.18 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).