Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C03866
Pert ID: BRD-K02113016
Compound Name: olaparib
Targets: PARP1|PARP2
MoA: PARP inhibitor
SMILES: Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1149 BRD-K02113016 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1161 BRD-K02113016 MCF??7.00 10 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
1323 BRD-K02113016 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9333 BRD-K02113016 AGS 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9639 BRD-K02113016 H1299 40 uM 6 h 0.19 0.77 0.0 0.0 0.0 0.0
9935 BRD-K02113016 HA1E 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10437 BRD-K02113016 HCT116 40 uM 6 h 0.21 0.87 0.01 0.0 0.0 0.0
11389 BRD-K02113016 NCIH2073 40 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.46
11961 BRD-K02113016 NCIH596 40 uM 6 h 0.0 0.0 0.0 0.2 0.72 0.02
12244 BRD-K02113016 NOMO1 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12706 BRD-K02113016 SW480 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13186 BRD-K02113016 U937 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13565 BRD-K02113016 VCAP 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91792 BRD-K02113016 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91927 BRD-K02113016 SKBR3 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
93641 BRD-K02113016 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93825 BRD-K02113016 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93954 BRD-K02113016 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94133 BRD-K02113016 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94222 BRD-K02113016 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94324 BRD-K02113016 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94368 BRD-K02113016 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94578 BRD-K02113016 CD34 0.04 uM 24 h 0.33 1.38 0.97 0.0 0.0 0.0
94713 BRD-K02113016 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.28 1.01 0.44
94773 BRD-K02113016 HME1 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.99
94916 BRD-K02113016 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.29
95042 BRD-K02113016 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95249 BRD-K02113016 SKL 0.37 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
116420 BRD-K02113016 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
116472 BRD-K02113016 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116522 BRD-K02113016 HT29 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
122834 BRD-K02113016 A375 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
123064 BRD-K02113016 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123113 BRD-K02113016 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123146 BRD-K02113016 PC3 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).