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CMap Candidate Details

Structure:
CMap ID: C00039
Pert ID: BRD-K56301217
Compound Name: ABT-737
Targets: BCL2|BCL2L1|BCL2L2
MoA: BCL inhibitor
SMILES: CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1334 BRD-K56301217 U2OS 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9448 BRD-K56301217 AGS 12 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.16
9754 BRD-K56301217 H1299 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10177 BRD-K56301217 HCC515 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10539 BRD-K56301217 HCT116 12 uM 6 h -0.19 -0.8 0.0 -0.23 -0.76 0.08
11514 BRD-K56301217 NCIH2073 12 uM 6 h 0.0 0.0 0.0 -0.27 -0.89 0.27
12075 BRD-K56301217 NCIH596 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12337 BRD-K56301217 NOMO1 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12816 BRD-K56301217 SW480 12 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
13300 BRD-K56301217 U937 12 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.86
13485 BRD-K56301217 VCAP 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91816 BRD-K56301217 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91843 BRD-K56301217 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91966 BRD-K56301217 SKBR3 10 uM 6 h -0.25 -1.02 0.19 -0.33 -1.12 0.96
93644 BRD-K56301217 ASC 10 uM 24 h -0.26 -1.07 0.26 0.24 0.86 0.16
93701 BRD-K56301217 CD34 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93749 BRD-K56301217 HA1E 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
93829 BRD-K56301217 HEK293 10 uM 24 h 0.0 0.0 0.0 0.28 1.01 0.44
93985 BRD-K56301217 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
94093 BRD-K56301217 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94154 BRD-K56301217 NPC 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
94226 BRD-K56301217 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94277 BRD-K56301217 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94328 BRD-K56301217 THP1 10 uM 24 h 0.2 0.85 0.0 0.0 0.0 0.0
94372 BRD-K56301217 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
117353 BRD-K56301217 A375 10 uM 24 h -0.17 -0.69 0.0 0.0 0.0 0.0
117524 BRD-K56301217 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123830 BRD-K56301217 A549 10 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
123939 BRD-K56301217 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123989 BRD-K56301217 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124090 BRD-K56301217 MCF??7.00 10 uM 24 h 0.2 0.85 0.01 0.28 1.01 0.44
124118 BRD-K56301217 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132222 BRD-K56301217 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132291 BRD-K56301217 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).