Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C03911
Pert ID: BRD-K67068943
Compound Name: ORE1001
Targets: ACE2
MoA: angiotensin converting enzyme inhibitor
SMILES: CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124700 BRD-K67068943 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124747 BRD-K67068943 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
124807 BRD-K67068943 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.07
124849 BRD-K67068943 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
124891 BRD-K67068943 THP1 0.04 uM 24 h 0.29 1.21 0.44 0.0 0.0 0.0
132669 BRD-K67068943 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132698 BRD-K67068943 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132727 BRD-K67068943 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132764 BRD-K67068943 HEK293 0.08 uM 24 h -0.23 -0.97 0.11 0.22 0.79 0.07
132794 BRD-K67068943 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132840 BRD-K67068943 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.55
132906 BRD-K67068943 MCF??7.00 2.22 uM 24 h 0.26 1.08 0.22 0.0 0.0 0.0
132962 BRD-K67068943 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).