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CMap Candidate Details

Structure:
CMap ID: C03924
Pert ID: BRD-A53576514
Compound Name: orphenadrine
Targets: GRIN1|GRIN2D|GRIN3A|GRIN3B|HRH1|SCN10A|SLC6A2
MoA: acetylcholine receptor antagonist
SMILES: CN(C)CCOC(c1ccccc1)c1ccccc1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3319 BRD-A53576514 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3692 BRD-A53576514 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44775 BRD-A53576514 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45095 BRD-A53576514 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.82
45894 BRD-A53576514 NPC 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
46211 BRD-A53576514 PHH 10 uM 24 h -0.27 -1.13 0.41 -0.29 -0.98 0.5
46526 BRD-A53576514 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
100215 BRD-A53576514 U2OS 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124353 BRD-A53576514 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124418 BRD-A53576514 JURKAT 3.33 uM 24 h -0.25 -1.04 0.21 -0.25 -0.85 0.2
124547 BRD-A53576514 YAPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
132332 BRD-A53576514 A375 0.03 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
132358 BRD-A53576514 A549 0.08 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
132390 BRD-A53576514 HA1E 0.08 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
132424 BRD-A53576514 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132463 BRD-A53576514 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132494 BRD-A53576514 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
132523 BRD-A53576514 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132553 BRD-A53576514 MDAMB231 0.74 uM 24 h -0.28 -1.18 0.5 0.0 0.0 0.0
132571 BRD-A53576514 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.12
132606 BRD-A53576514 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).