CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03932
Pert ID:	BRD-K25340465
Compound Name:	OSI-930
Targets:	KDR\|KIT
MoA:	KIT inhibitor; VEGFR inhibitor
SMILES:	FC(F)(F)Oc1ccc(NC(=O)c2sccc2NCc2ccnc3ccccc23)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91798	BRD-K25340465	HS578T	0.08 uM	6 h	0.0	0.0	0.0	-0.32	-1.07	0.76
91876	BRD-K25340465	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91959	BRD-K25340465	SKBR3	0.08 uM	6 h	-0.24	-0.99	0.13	-0.34	-1.16	1.11
92864	BRD-K25340465	A375	10 uM	24 h	-0.22	-0.93	0.07	0.0	0.0	0.0
92891	BRD-K25340465	A549	3.33 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.17
92922	BRD-K25340465	ASC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92984	BRD-K25340465	CD34	0.04 uM	24 h	0.0	0.0	0.0	0.36	1.28	1.34
93036	BRD-K25340465	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93074	BRD-K25340465	HEK293	0.04 uM	24 h	0.29	1.22	0.48	0.28	0.98	0.36
93120	BRD-K25340465	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93161	BRD-K25340465	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93210	BRD-K25340465	HUVEC	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93267	BRD-K25340465	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.22	0.79	0.07
93308	BRD-K25340465	MCF10A	3.33 uM	24 h	-0.22	-0.9	0.04	-0.26	-0.88	0.25
93350	BRD-K25340465	MDAMB231	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93412	BRD-K25340465	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93441	BRD-K25340465	PC3	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93475	BRD-K25340465	SKL	10 uM	24 h	0.0	0.0	0.0	-0.39	-1.33	1.74
93536	BRD-K25340465	THP1	3.33 uM	24 h	0.22	0.93	0.05	0.25	0.88	0.19
93577	BRD-K25340465	YAPC	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary