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CMap Candidate Details

Structure:
CMap ID: C03933
Pert ID: BRD-K42805893
Compound Name: osimertinib
Targets: EGFR
MoA: EGFR inhibitor
SMILES: COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92907 BRD-K42805893 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
92963 BRD-K42805893 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93018 BRD-K42805893 CD34 1.11 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
93104 BRD-K42805893 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93187 BRD-K42805893 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93244 BRD-K42805893 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93295 BRD-K42805893 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93331 BRD-K42805893 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93373 BRD-K42805893 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93432 BRD-K42805893 NPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93462 BRD-K42805893 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93499 BRD-K42805893 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93559 BRD-K42805893 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121580 BRD-K42805893 HA1E 3.33 uM 24 h -0.24 -1.01 0.16 -0.33 -1.11 0.92
121626 BRD-K42805893 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129575 BRD-K42805893 A375 2.22 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
129622 BRD-K42805893 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
129651 BRD-K42805893 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129714 BRD-K42805893 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.9 0.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).