CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03941
Pert ID:	BRD-K53417444
Compound Name:	OTS167
Targets:	MELK
MoA:	maternal embryonic leucine zipper kinase inhibitor
SMILES:	CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
92964	BRD-K53417444	ASC	10 uM	24 h	0.0	0.0	0.0	0.22	0.78	0.06
93020	BRD-K53417444	CD34	0.37 uM	24 h	0.31	1.29	0.64	0.0	0.0	0.0
93189	BRD-K53417444	HEPG2	3.33 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.31
93246	BRD-K53417444	HUVEC	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93405	BRD-K53417444	NPC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93519	BRD-K53417444	SKL	0.04 uM	24 h	0.31	1.29	0.64	0.0	0.0	0.0
124291	BRD-K53417444	A549	0.04 uM	24 h	0.31	1.3	0.68	0.0	0.0	0.0
124437	BRD-K53417444	JURKAT	0.125 uM	24 h	0.28	1.16	0.34	-0.26	-0.89	0.26
124529	BRD-K53417444	PC3	0.04 uM	24 h	0.0	0.0	0.0	0.26	0.94	0.28
132341	BRD-K53417444	A375	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132400	BRD-K53417444	HA1E	0.01 uM	24 h	0.2	0.85	0.01	0.0	0.0	0.0
132434	BRD-K53417444	HEK293	0.08 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
132451	BRD-K53417444	HELA	0.01 uM	24 h	0.22	0.91	0.03	-0.34	-1.14	1.04
132472	BRD-K53417444	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132508	BRD-K53417444	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132536	BRD-K53417444	MCF??7.00	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132564	BRD-K53417444	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132626	BRD-K53417444	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132650	BRD-K53417444	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.24

Summary