CMap Candidate Details
Structure:
| CMap ID: | C00398 |
| Pert ID: | BRD-K56032964 |
| Compound Name: | AP26113 |
| Targets: | ALK|EGFR |
| MoA: | ALK tyrosine kinase receptor inhibitor |
| SMILES: | COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N(C)C |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95549 | BRD-K56032964 | A549 | 4 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 95641 | BRD-K56032964 | U2OS | 4 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123530 | BRD-K56032964 | HA1E | 3.33 uM | 24 h | 0.24 | 0.99 | 0.1 | 0.36 | 1.26 | 1.29 |
| 123555 | BRD-K56032964 | HEK293 | 10 uM | 24 h | 0.18 | 0.75 | 0.0 | -0.39 | -1.31 | 1.69 |
| 123609 | BRD-K56032964 | HELA | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123636 | BRD-K56032964 | HT29 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.29 | 1.02 | 0.48 |
| 123674 | BRD-K56032964 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.23 | -0.78 | 0.1 |
| 131969 | BRD-K56032964 | A375 | 0.74 uM | 24 h | 0.28 | 1.16 | 0.34 | -0.32 | -1.09 | 0.84 |
| 132070 | BRD-K56032964 | MCF??7.00 | 0.25 uM | 24 h | -0.21 | -0.87 | 0.02 | 0.0 | 0.0 | 0.0 |
| 132101 | BRD-K56032964 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.1 | 0.87 |
| 132129 | BRD-K56032964 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.22 | -0.75 | 0.07 |