CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03989
Pert ID:	BRD-K53061490
Compound Name:	ozagrel
Targets:	TBXAS1
MoA:	thromboxane synthase inhibitor
SMILES:	OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
7683	BRD-K53061490	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.76	0.07
24681	BRD-K53061490	A549	10 uM	6 h	0.0	0.0	0.0	-0.3	-1.01	0.57
25387	BRD-K53061490	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91170	BRD-K53061490	HUH7	15 uM	72 h	0.19	0.8	0.0	0.16	0.58	0.0
99642	BRD-K53061490	U2OS	8 uM	6 h	0.0	0.0	0.0	-0.31	-1.05	0.72
124348	BRD-K53061490	HELA	3.33 uM	24 h	-0.27	-1.13	0.4	0.0	0.0	0.0
124413	BRD-K53061490	JURKAT	10 uM	24 h	0.22	0.91	0.03	-0.23	-0.76	0.07
124464	BRD-K53061490	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124544	BRD-K53061490	YAPC	1.11 uM	24 h	-0.19	-0.79	0.0	0.17	0.61	0.0
132327	BRD-K53061490	A375	0.01 uM	24 h	0.27	1.12	0.27	0.27	0.96	0.33
132386	BRD-K53061490	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.25	0.87	0.17
132420	BRD-K53061490	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132461	BRD-K53061490	HT29	2.22 uM	24 h	0.24	1.02	0.13	0.33	1.16	0.91
132490	BRD-K53061490	MCF10A	2.22 uM	24 h	-0.27	-1.14	0.42	0.0	0.0	0.0
132550	BRD-K53061490	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132570	BRD-K53061490	PC3	0.25 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.12
132600	BRD-K53061490	THP1	2.22 uM	24 h	0.0	0.0	0.0	0.21	0.75	0.04

Summary