CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03993
Pert ID:	BRD-K92041145
Compound Name:	O6-Benzylguanine
Targets:	MGMT
MoA:	O6-alkylguanine-DNA alkyltransferase inhibitor
SMILES:	Nc1nc(OCc2ccccc2)c2[nH]cnc2n1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
115952	BRD-K92041145	A375	0.04 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.76
115988	BRD-K92041145	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
116070	BRD-K92041145	HCC515	0.125 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.12
116113	BRD-K92041145	HEPG2	10 uM	24 h	-0.21	-0.88	0.03	0.0	0.0	0.0
116239	BRD-K92041145	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127828	BRD-K92041145	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127875	BRD-K92041145	HEK293	3.33 uM	24 h	0.29	1.19	0.42	0.0	0.0	0.0
127949	BRD-K92041145	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128002	BRD-K92041145	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
128083	BRD-K92041145	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135576	BRD-K92041145	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.24
135618	BRD-K92041145	HT29	0.08 uM	24 h	-0.26	-1.08	0.29	-0.34	-1.14	1.03
135667	BRD-K92041145	JURKAT	0.08 uM	24 h	0.0	0.0	0.0	0.34	1.2	1.13
135700	BRD-K92041145	MCF??7.00	0.03 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.22

Summary