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CMap Candidate Details

Structure:
CMap ID: C03997
Pert ID: BRD-K92991072
Compound Name: PAC-1
Targets: CASP3
MoA: caspase activator
SMILES: Oc1c(CC=C)cccc1\C=N\NC(=O)CN1CCN(Cc2ccccc2)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9009 BRD-K92991072 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9127 BRD-K92991072 A549 10 uM 24 h -0.2 -0.83 0.0 0.26 0.93 0.26
9854 BRD-K92991072 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9985 BRD-K92991072 HA1E 10 uM 24 h -0.25 -1.02 0.18 0.0 0.0 0.0
10355 BRD-K92991072 HCC515 10 uM 6 h 0.0 0.0 0.0 0.34 1.2 1.07
10629 BRD-K92991072 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10880 BRD-K92991072 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11041 BRD-K92991072 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11235 BRD-K92991072 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11614 BRD-K92991072 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11871 BRD-K92991072 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12171 BRD-K92991072 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.23 0.8 0.08
12409 BRD-K92991072 NOMO1 10 uM 6 h 0.0 0.0 0.0 -0.46 -1.56 15.65
12904 BRD-K92991072 SW480 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.14
13094 BRD-K92991072 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13399 BRD-K92991072 U937 10 uM 6 h -0.25 -1.04 0.21 0.0 0.0 0.0
13516 BRD-K92991072 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96897 BRD-K92991072 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.36
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).