CMap Candidate Details
Structure:
| CMap ID: | C03998 |
| Pert ID: | BRD-K62008436 |
| Compound Name: | paclitaxel |
| Targets: | BCL2|MAP2|MAP4|MAPT|NR1I2|TLR4|TUBB|TUBB1 |
| MoA: | tubulin polymerization inhibitor |
| SMILES: | CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 91252 | BRD-K62008436 | HUH7 | 4 uM | 72 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 99298 | BRD-K62008436 | U2OS | 2.22 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 117000 | BRD-K62008436 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 117039 | BRD-K62008436 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.3 | 1.59 |
| 117081 | BRD-K62008436 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.38 | -1.27 | 1.39 |
| 117115 | BRD-K62008436 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 117167 | BRD-K62008436 | HEPG2 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.23 | 0.83 | 0.11 |
| 117211 | BRD-K62008436 | HT29 | 10 uM | 24 h | -0.21 | -0.89 | 0.04 | 0.0 | 0.0 | 0.0 |
| 117253 | BRD-K62008436 | MCF??7.00 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.03 | 0.63 |
| 117290 | BRD-K62008436 | PC3 | 10 uM | 24 h | -0.29 | -1.23 | 0.63 | 0.0 | 0.0 | 0.0 |