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CMap Candidate Details

Structure:
CMap ID: C04018
Pert ID: BRD-K02130563
Compound Name: panobinostat
Targets: HDAC1|HDAC2|HDAC3|HDAC4|HDAC6|HDAC7|HDAC8|HDAC9
MoA: HDAC inhibitor
SMILES: Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1409 BRD-K02130563 U2OS 10 uM 6 h 0.18 0.76 0.0 0.0 0.0 0.0
25893 BRD-K02130563 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
26233 BRD-K02130563 ASC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
27821 BRD-K02130563 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28130 BRD-K02130563 NPC 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
28769 BRD-K02130563 PHH 10 uM 24 h -0.2 -0.85 0.01 -0.26 -0.87 0.24
29083 BRD-K02130563 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90388 BRD-K02130563 VCAP 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90894 BRD-K02130563 MCF10A 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97369 BRD-K02130563 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
97428 BRD-K02130563 NKDBA 1.11 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
118392 BRD-K02130563 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118461 BRD-K02130563 HA1E 0.04 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
118504 BRD-K02130563 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118548 BRD-K02130563 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
118590 BRD-K02130563 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
118654 BRD-K02130563 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).