CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04020
Pert ID:	BRD-A22380646
Compound Name:	pantoprazole
Targets:	ATP4A
MoA:	ATPase inhibitor
SMILES:	COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[nH]2)c1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4514	BRD-A22380646	HCC515	10 uM	6 h	0.18	0.75	0.0	-0.24	-0.8	0.12
25469	BRD-A22380646	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37457	BRD-A22380646	ASC	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.16	1.11
37793	BRD-A22380646	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38307	BRD-A22380646	NPC	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.36	2.02
38610	BRD-A22380646	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38832	BRD-A22380646	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91326	BRD-A22380646	HUH7	8 uM	72 h	-0.25	-1.06	0.26	-0.34	-1.15	1.07
95499	BRD-A22380646	A549	0.12 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
95657	BRD-A22380646	U2OS	0.12 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
121527	BRD-A22380646	YAPC	0.37 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.55
129412	BRD-A22380646	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129445	BRD-A22380646	HA1E	0.08 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.62
129471	BRD-A22380646	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129498	BRD-A22380646	HT29	0.01 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.23
129528	BRD-A22380646	MCF??7.00	0.74 uM	24 h	-0.2	-0.84	0.01	0.0	0.0	0.0
129563	BRD-A22380646	PC3	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary