CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04037
Pert ID:	BRD-K37991163
Compound Name:	paroxetine
Targets:	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|HTR2A\|SLC6A2\|SLC6A4
MoA:	selective serotonin reuptake inhibitor (SSRI)
SMILES:	Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5772	BRD-K37991163	HCC515	10 uM	6 h	0.0	0.0	0.0	0.28	0.99	0.41
6186	BRD-K37991163	PC3	10 uM	24 h	0.19	0.79	0.0	0.31	1.11	0.73
6541	BRD-K37991163	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24768	BRD-K37991163	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37149	BRD-K37991163	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37645	BRD-K37991163	ASC	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
37898	BRD-K37991163	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91328	BRD-K37991163	HUH7	10 uM	72 h	0.0	0.0	0.0	0.29	1.03	0.52
95341	BRD-K37991163	A549	10 uM	6 h	0.0	0.0	0.0	0.31	1.1	0.69
95377	BRD-K37991163	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95407	BRD-K37991163	U2OS	10 uM	24 h	-0.32	-1.32	0.83	0.0	0.0	0.0
123393	BRD-K37991163	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.35	1.25	1.29
123450	BRD-K37991163	THP1	10 uM	24 h	-0.28	-1.18	0.5	0.0	0.0	0.0
123485	BRD-K37991163	YAPC	10 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
131617	BRD-K37991163	HEK293	0.25 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
131652	BRD-K37991163	HELA	0.03 uM	24 h	0.2	0.81	0.0	0.2	0.7	0.02
131680	BRD-K37991163	HT29	2.22 uM	24 h	0.27	1.12	0.28	0.0	0.0	0.0
131710	BRD-K37991163	HUVEC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131763	BRD-K37991163	JURKAT	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131814	BRD-K37991163	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	0.32	1.12	0.77

Summary