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CMap Candidate Details

Structure:
CMap ID: C04047
Pert ID: BRD-K12867552
Compound Name: PCI-24781
Targets: HDAC1|HDAC2|HDAC3|HDAC6
MoA: HDAC inhibitor
SMILES: CN(C)Cc1c(oc2ccccc12)C(=O)NCCOc1ccc(cc1)C(=O)NO
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3143 BRD-K12867552 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3726 BRD-K12867552 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42302 BRD-K12867552 ASC 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.61
42635 BRD-K12867552 HEPG2 10 uM 6 h -0.16 -0.69 0.0 0.0 0.0 0.0
43494 BRD-K12867552 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.25
44074 BRD-K12867552 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95461 BRD-K12867552 U2OS 0.12 uM 6 h 0.0 0.0 0.0 -0.26 -0.89 0.26
96040 BRD-K12867552 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122241 BRD-K12867552 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122294 BRD-K12867552 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122327 BRD-K12867552 HELA 0.37 uM 24 h 0.3 1.27 0.58 -0.35 -1.17 1.12
122353 BRD-K12867552 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122384 BRD-K12867552 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.16
122433 BRD-K12867552 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122463 BRD-K12867552 THP1 10 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
122511 BRD-K12867552 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
130548 BRD-K12867552 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130615 BRD-K12867552 HEK293 0.25 uM 24 h 0.19 0.81 0.0 0.27 0.96 0.33
130698 BRD-K12867552 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130779 BRD-K12867552 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).