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CMap Candidate Details

Structure:
CMap ID: C04066
Pert ID: BRD-K97764662
Compound Name: PD-173074
Targets: FGFR1|FGFR2|FGFR3|FGFR4|FLT1|FLT4|KDR|PDGFRA|PDGFRB
MoA: FGFR inhibitor; VEGFR inhibitor
SMILES: CCN(CC)CCCCNc1ncc2cc(-c3cc(OC)cc(OC)c3)c(NC(=O)NC(C)(C)C)nc2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29984 BRD-K97764662 A375 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
33186 BRD-K97764662 SKB 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
34217 BRD-K97764662 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35642 BRD-K97764662 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35871 BRD-K97764662 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36388 BRD-K97764662 PHH 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
36900 BRD-K97764662 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91593 BRD-K97764662 HS578T 10 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
91701 BRD-K97764662 MDAMB231 10 uM 24 h -0.18 -0.74 0.0 0.29 1.03 0.52
92437 BRD-K97764662 A549 1.11 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
92468 BRD-K97764662 BT20 10 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.18
92503 BRD-K97764662 HA1E 10 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
92559 BRD-K97764662 HME1 10 uM 3 h 0.0 0.0 0.0 -0.41 -1.37 2.02
92671 BRD-K97764662 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
92714 BRD-K97764662 MCF10A 10 uM 24 h 0.27 1.13 0.29 0.28 0.98 0.37
92808 BRD-K97764662 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92829 BRD-K97764662 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117104 BRD-K97764662 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117154 BRD-K97764662 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117199 BRD-K97764662 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117243 BRD-K97764662 MCF??7.00 10 uM 24 h -0.21 -0.89 0.03 0.28 0.99 0.4
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).