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CMap Candidate Details

Structure:
CMap ID: C04068
Pert ID: BRD-K05104363
Compound Name: PD-184352
Targets: MAP2K1|MAP3K1|MAP3K2
MoA: MEK inhibitor
SMILES: Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30021 BRD-K05104363 A549 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
30342 BRD-K05104363 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
31248 BRD-K05104363 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.36 1.29 1.49
32333 BRD-K05104363 NPC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
35533 BRD-K05104363 NEU 10 uM 24 h -0.17 -0.71 0.0 0.0 0.0 0.0
36187 BRD-K05104363 PHH 10 uM 24 h -0.28 -1.15 0.43 0.0 0.0 0.0
36480 BRD-K05104363 SKB 10 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
36765 BRD-K05104363 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91639 BRD-K05104363 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91742 BRD-K05104363 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92026 BRD-K05104363 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92110 BRD-K05104363 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92143 BRD-K05104363 HS578T 0.12 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
92348 BRD-K05104363 PC3 10 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
95439 BRD-K05104363 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
97274 BRD-K05104363 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122703 BRD-K05104363 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122764 BRD-K05104363 MDAMB231 10 uM 24 h 0.21 0.88 0.01 0.0 0.0 0.0
122807 BRD-K05104363 YAPC 3.33 uM 24 h 0.2 0.83 0.0 0.32 1.13 0.84
130859 BRD-K05104363 A375 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
130903 BRD-K05104363 HA1E 2.22 uM 24 h 0.2 0.82 0.0 0.45 1.58 2.35
130928 BRD-K05104363 HEK293 2.22 uM 24 h 0.22 0.93 0.04 -0.22 -0.75 0.06
130954 BRD-K05104363 HELA 2.22 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
130990 BRD-K05104363 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
131025 BRD-K05104363 HUVEC 2.22 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).