CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04097
Pert ID:	BRD-K57569181
Compound Name:	pentoxifylline
Targets:	ADORA1\|ADORA2A\|ADORA2B\|ADRA2B\|NT5E\|PDE10A\|PDE1A\|PDE1B\|PDE1C\|PDE2A\|PDE3A\|PDE3B\|PDE4A\|PDE4B\|PDE4C\|PDE4D\|PDE5A\|PDE6A\|PDE6B\|PDE6C\|PDE6D\|PDE6G\|PDE6H\|PDE7A\|PDE7B\|PDE8A\|PDE8B\|PDE9A\|TNF
MoA:	phosphodiesterase inhibitor
SMILES:	CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5096	BRD-K57569181	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.95	0.41
37702	BRD-K57569181	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37926	BRD-K57569181	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38523	BRD-K57569181	NPC	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.35
38752	BRD-K57569181	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
51317	BRD-K57569181	MCF??7.00	10 uM	6 h	0.24	0.98	0.09	0.0	0.0	0.0
91336	BRD-K57569181	HUH7	12 uM	72 h	-0.22	-0.93	0.07	0.31	1.08	0.65
95535	BRD-K57569181	A549	1.11 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95674	BRD-K57569181	U2OS	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
96736	BRD-K57569181	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119898	BRD-K57569181	HCC515	0.01 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
119922	BRD-K57569181	PC3	0.01 uM	6 h	0.0	0.0	0.0	-0.28	-0.95	0.39
123871	BRD-K57569181	HA1E	0.04 uM	24 h	-0.21	-0.86	0.02	0.25	0.87	0.17
123899	BRD-K57569181	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124000	BRD-K57569181	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	-0.41	-1.39	2.02
124053	BRD-K57569181	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.72
124123	BRD-K57569181	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124182	BRD-K57569181	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124234	BRD-K57569181	YAPC	0.37 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.56
132195	BRD-K57569181	HELA	0.03 uM	24 h	-0.21	-0.87	0.02	0.0	0.0	0.0
132227	BRD-K57569181	HT29	0.03 uM	24 h	0.24	1.01	0.12	0.0	0.0	0.0

Summary