Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C04125
Pert ID: BRD-K37764012
Compound Name: PF-03758309
Targets: PAK4
MoA: p21 activated kinase inhibitor
SMILES: CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
94439 BRD-K37764012 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94506 BRD-K37764012 ASC 0.12 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
94533 BRD-K37764012 CD34 0.04 uM 24 h -0.28 -1.17 0.49 0.0 0.0 0.0
94586 BRD-K37764012 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94678 BRD-K37764012 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
94727 BRD-K37764012 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94781 BRD-K37764012 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94822 BRD-K37764012 HUVEC 0.12 uM 24 h 0.25 1.03 0.14 -0.34 -1.15 1.07
94874 BRD-K37764012 JURKAT 0.04 uM 24 h 0.22 0.9 0.03 -0.21 -0.71 0.03
95001 BRD-K37764012 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95048 BRD-K37764012 NPC 0.12 uM 24 h 0.23 0.94 0.06 -0.34 -1.13 0.98
95108 BRD-K37764012 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95146 BRD-K37764012 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95198 BRD-K37764012 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95259 BRD-K37764012 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123543 BRD-K37764012 HA1E 3.33 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
123585 BRD-K37764012 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123700 BRD-K37764012 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123727 BRD-K37764012 MCF??7.00 0.04 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
131990 BRD-K37764012 A375 2.22 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
132146 BRD-K37764012 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).