CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04126
Pert ID:	BRD-K68747584
Compound Name:	PF-03814735
Targets:	AURKA\|AURKB
MoA:	Aurora kinase inhibitor
SMILES:	CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c1cc(Nc3ncc(c(NC4CCC4)n3)C(F)(F)F)ccc21
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126356	BRD-K68747584	A375	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126373	BRD-K68747584	A549	3.33 uM	24 h	-0.3	-1.26	0.72	0.0	0.0	0.0
126423	BRD-K68747584	HEK293	1.11 uM	24 h	0.28	1.18	0.39	-0.31	-1.05	0.69
126468	BRD-K68747584	HELA	1.11 uM	24 h	0.0	0.0	0.0	0.37	1.31	1.59
126514	BRD-K68747584	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126549	BRD-K68747584	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.3	1.05	0.57
126571	BRD-K68747584	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134391	BRD-K68747584	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134453	BRD-K68747584	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134490	BRD-K68747584	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	-0.39	-1.3	1.59
134562	BRD-K68747584	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134646	BRD-K68747584	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.3	1.06	0.61

Summary