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CMap Candidate Details

Structure:
CMap ID: C04128
Pert ID: BRD-K94420399
Compound Name: PF-04136309
Targets:
MoA: CC chemokine receptor antagonist
SMILES: O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccc(cn1)-c1ncccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128383 BRD-K94420399 A549 0.37 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.54
128438 BRD-K94420399 HEK293 10 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
128479 BRD-K94420399 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128505 BRD-K94420399 HT29 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
128548 BRD-K94420399 JURKAT 1.11 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
128609 BRD-K94420399 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128640 BRD-K94420399 MDAMB231 3.33 uM 24 h 0.28 1.17 0.37 0.0 0.0 0.0
128681 BRD-K94420399 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128720 BRD-K94420399 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128766 BRD-K94420399 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136180 BRD-K94420399 A375 0.01 uM 24 h -0.29 -1.19 0.53 0.25 0.88 0.19
136225 BRD-K94420399 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
136311 BRD-K94420399 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).