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CMap Candidate Details

Structure:
CMap ID: C04131
Pert ID: BRD-K50031829
Compound Name: PF-04447943
Targets: PDE9A
MoA: phosphodiesterase inhibitor
SMILES: C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125265 BRD-K50031829 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125285 BRD-K50031829 HA1E 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125335 BRD-K50031829 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
125383 BRD-K50031829 HT29 1.11 uM 24 h -0.25 -1.05 0.23 0.25 0.87 0.17
125462 BRD-K50031829 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125504 BRD-K50031829 PC3 0.125 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
133350 BRD-K50031829 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133438 BRD-K50031829 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133494 BRD-K50031829 JURKAT 0.01 uM 24 h -0.3 -1.23 0.64 0.0 0.0 0.0
133529 BRD-K50031829 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.18 0.62 0.0
133569 BRD-K50031829 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133615 BRD-K50031829 THP1 0.01 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
133646 BRD-K50031829 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).