CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04132
Pert ID:	BRD-K86816506
Compound Name:	PF-04457845
Targets:	FAAH
MoA:	FAAH inhibitor
SMILES:	FC(F)(F)c1ccc(Oc2cccc(C=C3CCN(CC3)C(=O)Nc3cccnn3)c2)nc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96855	BRD-K86816506	A375	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.85	0.2
125993	BRD-K86816506	A549	10 uM	24 h	-0.3	-1.27	0.73	0.0	0.0	0.0
126042	BRD-K86816506	HELA	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.06	0.72
126065	BRD-K86816506	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126104	BRD-K86816506	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.89	0.27
126159	BRD-K86816506	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.58
126210	BRD-K86816506	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126227	BRD-K86816506	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126278	BRD-K86816506	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126329	BRD-K86816506	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.31	1.1	0.7
126351	BRD-K86816506	YAPC	10 uM	24 h	-0.2	-0.85	0.01	0.2	0.7	0.02
134079	BRD-K86816506	HA1E	0.03 uM	24 h	-0.2	-0.82	0.0	-0.34	-1.15	1.07
134133	BRD-K86816506	HEK293	2.22 uM	24 h	0.0	0.0	0.0	-0.5	-1.68	15.65
134278	BRD-K86816506	MDAMB231	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary