CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04133
Pert ID:	BRD-K30550578
Compound Name:	PF-04620110
Targets:	DGAT1
MoA:	diacylglycerol O acyltransferase inhibitor
SMILES:	Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
121938	BRD-K30550578	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121965	BRD-K30550578	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121986	BRD-K30550578	HELA	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122015	BRD-K30550578	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122061	BRD-K30550578	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122115	BRD-K30550578	MCF??7.00	0.04 uM	24 h	-0.22	-0.93	0.07	-0.35	-1.16	1.11
122146	BRD-K30550578	MDAMB231	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122199	BRD-K30550578	THP1	0.37 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.78
122222	BRD-K30550578	YAPC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130188	BRD-K30550578	A375	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130208	BRD-K30550578	A549	0.08 uM	24 h	0.0	0.0	0.0	-0.22	-0.73	0.05
130362	BRD-K30550578	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130409	BRD-K30550578	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.2	0.72	0.02
130482	BRD-K30550578	PC3	0.01 uM	24 h	0.21	0.86	0.01	0.21	0.75	0.04

Summary