CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04134
Pert ID:	BRD-K07310275
Compound Name:	PF-04691502
Targets:	MTOR\|PIK3CA
MoA:	mTOR inhibitor; PI3K inhibitor
SMILES:	COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OCCO)c1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
505	BRD-K07310275	BJAB	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
559	BRD-K07310275	HBL1	10 uM	4 h	-0.25	-1.02	0.19	0.2	0.71	0.02
602	BRD-K07310275	K562	10 uM	4 h	0.0	0.0	0.0	-0.4	-1.35	1.86
641	BRD-K07310275	KMS34	0.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
687	BRD-K07310275	MINO	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
734	BRD-K07310275	NALM6	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
768	BRD-K07310275	OCILY19	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
837	BRD-K07310275	OCILY3	10 uM	4 h	-0.21	-0.86	0.02	-0.23	-0.76	0.07
877	BRD-K07310275	SKMEL5	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
917	BRD-K07310275	THP1	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
941	BRD-K07310275	TMD8	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.96	0.44
122584	BRD-K07310275	A549	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.53
122607	BRD-K07310275	HA1E	10 uM	24 h	0.21	0.89	0.02	0.0	0.0	0.0
122642	BRD-K07310275	HEK293	3.33 uM	24 h	0.0	0.0	0.0	-0.4	-1.34	1.85
122688	BRD-K07310275	HT29	1.11 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.01
122735	BRD-K07310275	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	-0.22	-0.76	0.07
122801	BRD-K07310275	PC3	3.33 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.13
122822	BRD-K07310275	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130872	BRD-K07310275	A375	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130977	BRD-K07310275	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131057	BRD-K07310275	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131092	BRD-K07310275	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
131129	BRD-K07310275	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary