CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04151
Pert ID:	BRD-K79239947
Compound Name:	PF-573228
Targets:	CDK1\|CDK2\|CDK7\|GSK3B\|IKBKB
MoA:	focal adhesion kinase inhibitor
SMILES:	CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
94487	BRD-K79239947	ASC	10 uM	24 h	0.0	0.0	0.0	-0.18	-0.6	0.0
94556	BRD-K79239947	CD34	10 uM	24 h	-0.32	-1.33	0.89	-0.29	-0.97	0.45
94602	BRD-K79239947	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09
94647	BRD-K79239947	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94696	BRD-K79239947	HELA	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94751	BRD-K79239947	HME1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94843	BRD-K79239947	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94896	BRD-K79239947	JURKAT	10 uM	24 h	0.24	1.02	0.12	0.0	0.0	0.0
94940	BRD-K79239947	MCF10A	10 uM	24 h	0.19	0.78	0.0	0.0	0.0	0.0
95021	BRD-K79239947	NEU	10 uM	24 h	0.34	1.41	1.03	0.0	0.0	0.0
95081	BRD-K79239947	NPC	10 uM	24 h	0.33	1.38	0.97	0.0	0.0	0.0
95169	BRD-K79239947	SHSY5Y	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95213	BRD-K79239947	SKL	10 uM	24 h	0.0	0.0	0.0	0.37	1.3	1.49
95279	BRD-K79239947	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117013	BRD-K79239947	A375	10 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0
117050	BRD-K79239947	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117090	BRD-K79239947	HA1E	10 uM	24 h	0.27	1.14	0.32	0.0	0.0	0.0
117179	BRD-K79239947	HEPG2	10 uM	24 h	0.0	0.0	0.0	0.21	0.73	0.03
117224	BRD-K79239947	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117264	BRD-K79239947	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117298	BRD-K79239947	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary