CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00416
Pert ID:	BRD-K70358946
Compound Name:	aripiprazole
Targets:	ADRA1A\|ADRA1B\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HRH1\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR2A\|HTR2C\|HTR3A\|HTR6\|HTR7
MoA:	serotonin receptor agonist; serotonin receptor antagonist
SMILES:	Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1456	BRD-K70358946	NPC	25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25529	BRD-K70358946	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
52189	BRD-K70358946	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91136	BRD-K70358946	HUH7	8 uM	72 h	0.0	0.0	0.0	0.3	1.05	0.57
126360	BRD-K70358946	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126377	BRD-K70358946	A549	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.27	1.39
126429	BRD-K70358946	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126471	BRD-K70358946	HELA	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
126517	BRD-K70358946	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126551	BRD-K70358946	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126576	BRD-K70358946	PC3	10 uM	24 h	0.3	1.23	0.5	0.24	0.83	0.12
126596	BRD-K70358946	YAPC	10 uM	24 h	-0.25	-1.06	0.25	0.0	0.0	0.0
134395	BRD-K70358946	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134458	BRD-K70358946	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134495	BRD-K70358946	HUVEC	0.74 uM	24 h	-0.21	-0.88	0.03	0.0	0.0	0.0

Summary