CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04163
Pert ID:	BRD-K95880107
Compound Name:	PH-797804
Targets:	MAPK11\|MAPK14
MoA:	p38 MAPK inhibitor
SMILES:	CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
128108	BRD-K95880107	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128219	BRD-K95880107	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.9
128298	BRD-K95880107	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128352	BRD-K95880107	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135775	BRD-K95880107	A549	0.08 uM	24 h	0.0	0.0	0.0	0.3	1.06	0.59
135808	BRD-K95880107	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.26
135848	BRD-K95880107	HEK293	0.25 uM	24 h	0.0	0.0	0.0	0.24	0.86	0.16
135893	BRD-K95880107	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135939	BRD-K95880107	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135982	BRD-K95880107	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136027	BRD-K95880107	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136057	BRD-K95880107	PC3	2.22 uM	24 h	-0.2	-0.81	0.0	0.0	0.0	0.0
136128	BRD-K95880107	YAPC	2.22 uM	24 h	0.21	0.88	0.02	-0.29	-0.98	0.49

Summary