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CMap Candidate Details

Structure:
CMap ID: C04167
Pert ID: BRD-K50000283
Compound Name: PHA-767491
Targets: CDK1|RPS6KB1
MoA: CDC inhibitor
SMILES: O=C1NCCc2[nH]c(cc12)-c1ccncc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92871 BRD-K50000283 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92898 BRD-K50000283 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
92957 BRD-K50000283 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93001 BRD-K50000283 CD34 3.33 uM 24 h 0.31 1.3 0.69 0.0 0.0 0.0
93044 BRD-K50000283 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
93089 BRD-K50000283 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93131 BRD-K50000283 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93174 BRD-K50000283 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93227 BRD-K50000283 HUVEC 1.11 uM 24 h 0.3 1.23 0.5 0.0 0.0 0.0
93281 BRD-K50000283 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93319 BRD-K50000283 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93362 BRD-K50000283 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93399 BRD-K50000283 NPC 1.11 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
93448 BRD-K50000283 PC3 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93513 BRD-K50000283 SKL 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93547 BRD-K50000283 THP1 1.11 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
93587 BRD-K50000283 YAPC 3.33 uM 24 h 0.27 1.11 0.25 -0.22 -0.73 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).