CMap Candidate Details
Structure:
| CMap ID: | C04169 |
| Pert ID: | BRD-K60997853 |
| Compound Name: | PHA-848125 |
| Targets: | CDK2|CDK4|CDK7|NTRK1 |
| MoA: | CDK inhibitor; growth factor receptor inhibitor |
| SMILES: | CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 90876 | BRD-K60997853 | MCF10A | 3.33 uM | 3 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.32 | 1.71 |
| 97308 | BRD-K60997853 | HAP1 | 0.66 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.06 | 0.58 |
| 123581 | BRD-K60997853 | HEK293 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.43 | -1.44 | 15.35 |
| 123656 | BRD-K60997853 | HT29 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131988 | BRD-K60997853 | A375 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132016 | BRD-K60997853 | HA1E | 2.22 uM | 24 h | 0.25 | 1.05 | 0.16 | 0.0 | 0.0 | 0.0 |
| 132042 | BRD-K60997853 | HELA | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132089 | BRD-K60997853 | MCF??7.00 | 0.03 uM | 24 h | -0.19 | -0.78 | 0.0 | -0.23 | -0.78 | 0.09 |
| 132120 | BRD-K60997853 | PC3 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132144 | BRD-K60997853 | YAPC | 0.74 uM | 24 h | -0.23 | -0.94 | 0.08 | 0.0 | 0.0 | 0.0 |