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CMap Candidate Details

Structure:
CMap ID: C04174
Pert ID: BRD-K46937689
Compound Name: phenazone
Targets: PTGS1|PTGS2
MoA: cyclooxygenase inhibitor
SMILES: Cc1cc(=O)n(-c2ccccc2)n1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5639 BRD-K46937689 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.07
6027 BRD-K46937689 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6335 BRD-K46937689 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37673 BRD-K46937689 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38497 BRD-K46937689 NPC 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
53399 BRD-K46937689 HEPG2 2.5 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
53514 BRD-K46937689 HUH7 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53667 BRD-K46937689 PHH 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125588 BRD-K46937689 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125617 BRD-K46937689 A549 10 uM 24 h 0.27 1.13 0.28 0.27 0.96 0.33
125655 BRD-K46937689 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125740 BRD-K46937689 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125897 BRD-K46937689 THP1 1.11 uM 24 h 0.27 1.12 0.28 0.0 0.0 0.0
125938 BRD-K46937689 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133704 BRD-K46937689 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133772 BRD-K46937689 HELA 0.01 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
133828 BRD-K46937689 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
133862 BRD-K46937689 MCF10A 0.08 uM 24 h 0.19 0.78 0.0 0.29 1.01 0.45
133886 BRD-K46937689 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133917 BRD-K46937689 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
133946 BRD-K46937689 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).